The use of natural substances, such as enzymes from biological sources or whole cells to speed up chemical reactions.
Interested in finding out more or interested in contributing an article? Then please contact our editor, Chaosheng Luo, Scientific Editor, Email: [email protected]
Enzymatic intermolecular Diels-Alder reactions in synthesis: From nature to designThe Diels-Alder (D-A) reaction is one of the most critical chemical transformations to construct C–C bonds with predictable regio- and stereo-selectivities. It has been widely used as a retrosynthetic disconnection in synthetic chemistry. Although significant advances have been made, synthetic challenges remain in how to precisely control the stereochemistry of intermolecular Diels-Alder reaction. Enzymes are well known for their remarkable catalytic efficiency and selectivity compared with chemo-catalysts.