Biocatalysis
The use of natural substances, such as enzymes from biological sources or whole cells to speed up chemical reactions.
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Enzymatic intermolecular Diels-Alder reactions in synthesis: From nature to design
The Diels-Alder (D-A) reaction is one of the most critical chemical transformations to construct C–C bonds with predictable regio- and stereo-selectivities. It has been widely used as a retrosynthetic disconnection in synthetic chemistry. Although significant advances have been made, synthetic challenges remain in how to precisely control the stereochemistry of intermolecular Diels-Alder reaction. Enzymes are well known for their remarkable catalytic efficiency and selectivity compared with chemo-catalysts.
