Welcome to the inaugural issue of Tetrahedron Chem, our first gold open access organic chemistry title, with synthesis at the core representing a unique addition to the Tetrahedron family.
Sixty-five years ago, back in 1957, the first issue of Tetrahedron was published. Founded by Sir Robert Robinson and Professor Robert Woodward, Tetrahedron has long been a trusted source of knowledge and inspiration for several generations of international organic chemists. This exciting milestone is being celebrated with a 65th anniversary collection of perspective articles in Tetrahedron and Tetrahedron Letters.
This editorial also marks another significant milestone for us. The field of organic chemistry is transforming rapidly, with changes in research directions, conduct, collaboration, and the way we disseminate new results. To support these changes, our mission is clear. We're launching Tetrahedron Chem, a new high-impact organic chemistry title benefitting from a dedicated professional editorial team, supported by a prestigious advisory board, and established to best serve a global and diverse community of organic chemists, inspired by Robinson's founding ethos [
[1]
].- Robinson Robert
Tetrahedron. 1957; 1 (pg. 1)https://doi.org/10.1016/0040-4020(57)85002-9
As professional Scientific Editors, we offer a fast and fair peer review process with similar expectations for rigor and transparency as Chem, the prestigious title from Cell Press. We're focused on selecting the highest quality manuscripts for each volume, and we're excited to offer article level promotion to showcase cutting-edge research from laboratories around the world and give organic synthesis the platform that it truly deserves.
Tetrahedron Chem publishes significant advances and insights from those working directly in organic synthesis as well as those working at the interfaces of biology and materials science. The scope covers all fundamental and applied aspects of organic chemistry. The future of organic synthesis is bright, we're excited to be a part of it and we look forward to sharing more inspirational and interesting papers in the coming months.
Volume 1 of our journal includes two comprehensive reviews, one on axially chiral alkenes from Bin Tan [
[2]
], who has made pioneering contributions in this area, another highlights the multiple strategies available to transform remote C(sp3)-H bonds in amino acids and peptides from Debabrata Maiti [[3]
]. In addition, a key perspective from the lab of Song Lin highlights the use of data science tools to drive innovation in synthetic electrochemistry [[4]
].We also have nine research articles. The axial chirality thread continues in a study by John Fossey and co-workers on the restricted rotation of axially chiral atropisomeric 1,5-disubstituted triazole systems [
[5]
], and C–H activation is exploited by Georg Manolikakes and colleagues, who report a C–H-functionalization and synthesis of sulfonylated N-heterocycles in an operationally simple one-pot procedure [[6]
]. Hiroki Oguri reports his team's successful efforts towards chemo-enzymatic total synthesis of bis-tetrahydroisoquinoline alkaloids [[7]
], and Tim Newhouse and co-workers disclose a concise synthesis of (−)-melazolide B and (−)-actinidiolide [[8]
]. Catalysis is well represented, as Liu-Zhu Gong and co-workers report a modular route to chiral cyclopentanes by palladium and chiral squaramide relay catalysis [[9]
]. A full paper from the team of Feng Shi reports the organocatalytic asymmetric synthesis of indoline-connected allenes bearing multiple chiral elements in a single step [[10]
], and photocatalysis is showcased in a paper from Min Shi, Yin Wei and Zhen Liu, on a photocatalytic interrupted Cloke-Wilson rearrangement for the synthesis of oxy-bridged macrocycles [[11]
]. Synthetic supramolecular chemistry is highlighted with a report from Qing He and team describing a facile and efficient synthetic approach to emissive superphanes with unique host-guest binding properties [[12]
]. Finally, a computational study from Israel Fernandez and co-workers explores catalysis by non-covalent interactions, with bis-selenium cations as chalcogen bond donors [[13]
].Our editor team is based in Oxford, UK and Shenzhen, China; details to reach out to us by email can be found on our contact page.
Chaosheng Luo obtained his PhD degree in organic chemistry from Peking University in 2015, followed by postdoctoral positions at MIT, Colorado State University and EPFL. He was trained in the field of synthetic methodology and chemical biology.
Marta Meazza obtained her PhD in organic chemistry in 2016 from the University of Southampton, followed by postdoctoral positions at Aarhus University and the University of Southampton, and a research assistant role in a pharmaceutical company. Her expertise covers organic synthesis and methodology specializing in organocatalysis, photocatalysis and functional organic materials.
Jessica Pancholi obtained her PhD in organic supramolecular chemistry in 2015 from Queen Mary University of London, followed by postdoctoral positions at University College London and the University of Oxford. Her expertise covers organic, bioorganic, supramolecular, medicinal synthetic chemistry and functional organic materials.
A warm thank you to all of our authors for contributing your excellent work to this inaugural volume, and to every reviewer and member of our Advisory Board for your insightful comments, valuable input and support. We are also grateful to Robert Eagling, Vjekoslav Dekaris and Ilaria Cianchetta, our colleagues at Chem and Chem Catalysis, for helpful discussion, inspiration and support along the way.
We hope that you enjoy these first articles and that you will consider Tetrahedron Chem for your future work. We wish you every success with your research, hope to meet many of you virtually or in person in the coming months, and look forward to shaping this new journal together.
Chaosheng, Marta and Jessica.
References
- Tetrahedron. 1957; 1 (pg. 1)https://doi.org/10.1016/0040-4020(57)85002-9
- Axially chiral alkenes: atroposelective synthesis and applications.Tetrahedron Chem. 2022; 1: 100009
- Strategies to transform remote C(sp3)-H bonds of amino acid derivatives.Tetrahedron Chem. 2022; 1: 100005
- Working at the interfaces of data science and synthetic electrochemistry.Tetrahedron Chem. 2022; : 100012
- Enantiomer stability of atropisomeric 1,5-disubstituted 1,2,3-triazoles.Tetrahedron Chem. 2022; 1: 100004
- Direct C–H-sulfonylation of 6-membered nitrogen-heteroaromatics.Tetrahedron Chem. 2022; 1: 100003
- Chemo-enzymatic total syntheses of bis-tetrahydroisoquinoline alkaloids and systematic exploration of the substrate scope of SfmC.Tetrahedron Chem. 2022; : 100010
- Synthesis of melazolide B, a degraded limonoid, from a natural terpene precursor.Tetrahedron Chem. 2022; : 100011
- Modular access to chiral cyclopentanes via formal [2+2+1] annulation enabled by palladium/chiral squaramide relay catalysis.Tetrahedron Chem. 2022; 1: 100002
- Organocatalytic asymmetric synthesis of bioactive hexahydropyrrolo[2,3-b]indole-containing tetrasubstituted allenes bearing multiple chiral elements.Tetrahedron Chem. 2022; 1: 100007
- Visible-light-mediated interrupted Cloke-Wilson rearrangement of cyclopropyl ketones to construct oxy-bridged macrocyclic framework.Tetrahedron Chem. 2022; 1: 100001
- Facile and efficient preparation, functionalization and unique properties.Tetrahedron Chem. 2022; 1: 100006
- Understanding the catalysis by bis-selenonium cations as bidentate chalcogen bond donors.Tetrahedron Chem. 2022; 1: 100008
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