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Tetrahedron looking back, Tetrahedron Chem looking forward

        Welcome to the inaugural issue of Tetrahedron Chem, our first gold open access organic chemistry title, with synthesis at the core representing a unique addition to the Tetrahedron family.
        Sixty-five years ago, back in 1957, the first issue of Tetrahedron was published. Founded by Sir Robert Robinson and Professor Robert Woodward, Tetrahedron has long been a trusted source of knowledge and inspiration for several generations of international organic chemists. This exciting milestone is being celebrated with a 65th anniversary collection of perspective articles in Tetrahedron and Tetrahedron Letters.
        This editorial also marks another significant milestone for us. The field of organic chemistry is transforming rapidly, with changes in research directions, conduct, collaboration, and the way we disseminate new results. To support these changes, our mission is clear. We're launching Tetrahedron Chem, a new high-impact organic chemistry title benefitting from a dedicated professional editorial team, supported by a prestigious advisory board, and established to best serve a global and diverse community of organic chemists, inspired by Robinson's founding ethos [].
        As professional Scientific Editors, we offer a fast and fair peer review process with similar expectations for rigor and transparency as Chem, the prestigious title from Cell Press. We're focused on selecting the highest quality manuscripts for each volume, and we're excited to offer article level promotion to showcase cutting-edge research from laboratories around the world and give organic synthesis the platform that it truly deserves.
        Tetrahedron Chem publishes significant advances and insights from those working directly in organic synthesis as well as those working at the interfaces of biology and materials science. The scope covers all fundamental and applied aspects of organic chemistry. The future of organic synthesis is bright, we're excited to be a part of it and we look forward to sharing more inspirational and interesting papers in the coming months.
        Volume 1 of our journal includes two comprehensive reviews, one on axially chiral alkenes from Bin Tan [
        • Wu San
        • Xiang Shao-Hua
        • Cheng Jun Kee
        • Tan Bin
        Axially chiral alkenes: atroposelective synthesis and applications.
        ], who has made pioneering contributions in this area, another highlights the multiple strategies available to transform remote C(sp3)-H bonds in amino acids and peptides from Debabrata Maiti [
        • Sen Supreeta
        • Das Jayabrata
        • Maiti Debabrata
        Strategies to transform remote C(sp3)-H bonds of amino acid derivatives.
        ]. In addition, a key perspective from the lab of Song Lin highlights the use of data science tools to drive innovation in synthetic electrochemistry [
        • Martinez Alvarado Jesus I.
        • Meinhardt Jonathan M.
        • Lin Song
        Working at the interfaces of data science and synthetic electrochemistry.
        ].
        We also have nine research articles. The axial chirality thread continues in a study by John Fossey and co-workers on the restricted rotation of axially chiral atropisomeric 1,5-disubstituted triazole systems [
        • Meloni Fernanda
        • Brittain William D.G.
        • Male Louise
        • Cécile S.
        • Le Duff
        • Buckley Benjamin R.
        • Leach Andrew G.
        • Fossey John S.
        Enantiomer stability of atropisomeric 1,5-disubstituted 1,2,3-triazoles.
        ], and C–H activation is exploited by Georg Manolikakes and colleagues, who report a C–H-functionalization and synthesis of sulfonylated N-heterocycles in an operationally simple one-pot procedure [
        • Friedrich Marius
        • Schulz Lisa
        • Hofman Kamil
        • Zangl Rene
        • Morgner Nina
        • Shaaban Saad
        • Manolikakes Georg
        Direct C–H-sulfonylation of 6-membered nitrogen-heteroaromatics.
        ]. Hiroki Oguri reports his team's successful efforts towards chemo-enzymatic total synthesis of bis-tetrahydroisoquinoline alkaloids [
        • Tanifuji Ryo
        • Haraguchi Naoto
        • Oguri Hiroki
        Chemo-enzymatic total syntheses of bis-tetrahydroisoquinoline alkaloids and systematic exploration of the substrate scope of SfmC.
        ], and Tim Newhouse and co-workers disclose a concise synthesis of (−)-melazolide B and (−)-actinidiolide [
        • Liu Yannan
        • Schuppe Alexander W.
        • Zhao Yizhou
        • Lee Jaehoo
        • Newhouse Timothy R.
        Synthesis of melazolide B, a degraded limonoid, from a natural terpene precursor.
        ]. Catalysis is well represented, as Liu-Zhu Gong and co-workers report a modular route to chiral cyclopentanes by palladium and chiral squaramide relay catalysis [
        • Fan Lian-Feng
        • Liu Rui
        • Wang Pu-Sheng
        • Gong Liu-Zhu
        Modular access to chiral cyclopentanes via formal [2+2+1] annulation enabled by palladium/chiral squaramide relay catalysis.
        ]. A full paper from the team of Feng Shi reports the organocatalytic asymmetric synthesis of indoline-connected allenes bearing multiple chiral elements in a single step [
        • Wang Jing-Yi
        • Zhang Shuming
        • Xian-Yang Yu
        • Wang Yu-Hao
        • Wan Hong-Lin
        • Zhang Shu
        • Tan Wei
        • Shi Feng
        Organocatalytic asymmetric synthesis of bioactive hexahydropyrrolo[2,3-b]indole-containing tetrasubstituted allenes bearing multiple chiral elements.
        ], and photocatalysis is showcased in a paper from Min Shi, Yin Wei and Zhen Liu, on a photocatalytic interrupted Cloke-Wilson rearrangement for the synthesis of oxy-bridged macrocycles [
        • Liu Zhen
        • Yin Wei
        • Shi Min
        Visible-light-mediated interrupted Cloke-Wilson rearrangement of cyclopropyl ketones to construct oxy-bridged macrocyclic framework.
        ]. Synthetic supramolecular chemistry is highlighted with a report from Qing He and team describing a facile and efficient synthetic approach to emissive superphanes with unique host-guest binding properties [
        • Li Aimin
        • Liu Yuanchu
        • Zhou Wei
        • Jiang Yunqi
        • He Qing
        • Superphanes
        Facile and efficient preparation, functionalization and unique properties.
        ]. Finally, a computational study from Israel Fernandez and co-workers explores catalysis by non-covalent interactions, with bis-selenium cations as chalcogen bond donors [
        • Portela Susana
        • Fernández Israel
        Understanding the catalysis by bis-selenonium cations as bidentate chalcogen bond donors.
        ].
        Our editor team is based in Oxford, UK and Shenzhen, China; details to reach out to us by email can be found on our contact page.
        Chaosheng Luo obtained his PhD degree in organic chemistry from Peking University in 2015, followed by postdoctoral positions at MIT, Colorado State University and EPFL. He was trained in the field of synthetic methodology and chemical biology.
        Marta Meazza obtained her PhD in organic chemistry in 2016 from the University of Southampton, followed by postdoctoral positions at Aarhus University and the University of Southampton, and a research assistant role in a pharmaceutical company. Her expertise covers organic synthesis and methodology specializing in organocatalysis, photocatalysis and functional organic materials.
        Jessica Pancholi obtained her PhD in organic supramolecular chemistry in 2015 from Queen Mary University of London, followed by postdoctoral positions at University College London and the University of Oxford. Her expertise covers organic, bioorganic, supramolecular, medicinal synthetic chemistry and functional organic materials.
        A warm thank you to all of our authors for contributing your excellent work to this inaugural volume, and to every reviewer and member of our Advisory Board for your insightful comments, valuable input and support. We are also grateful to Robert Eagling, Vjekoslav Dekaris and Ilaria Cianchetta, our colleagues at Chem and Chem Catalysis, for helpful discussion, inspiration and support along the way.
        We hope that you enjoy these first articles and that you will consider Tetrahedron Chem for your future work. We wish you every success with your research, hope to meet many of you virtually or in person in the coming months, and look forward to shaping this new journal together.
        Chaosheng, Marta and Jessica.

        References

          • Robinson Robert
          Tetrahedron. 1957; 1 (pg. 1)https://doi.org/10.1016/0040-4020(57)85002-9
          • Wu San
          • Xiang Shao-Hua
          • Cheng Jun Kee
          • Tan Bin
          Axially chiral alkenes: atroposelective synthesis and applications.
          Tetrahedron Chem. 2022; 1: 100009
          • Sen Supreeta
          • Das Jayabrata
          • Maiti Debabrata
          Strategies to transform remote C(sp3)-H bonds of amino acid derivatives.
          Tetrahedron Chem. 2022; 1: 100005
          • Martinez Alvarado Jesus I.
          • Meinhardt Jonathan M.
          • Lin Song
          Working at the interfaces of data science and synthetic electrochemistry.
          Tetrahedron Chem. 2022; : 100012
          • Meloni Fernanda
          • Brittain William D.G.
          • Male Louise
          • Cécile S.
          • Le Duff
          • Buckley Benjamin R.
          • Leach Andrew G.
          • Fossey John S.
          Enantiomer stability of atropisomeric 1,5-disubstituted 1,2,3-triazoles.
          Tetrahedron Chem. 2022; 1: 100004
          • Friedrich Marius
          • Schulz Lisa
          • Hofman Kamil
          • Zangl Rene
          • Morgner Nina
          • Shaaban Saad
          • Manolikakes Georg
          Direct C–H-sulfonylation of 6-membered nitrogen-heteroaromatics.
          Tetrahedron Chem. 2022; 1: 100003
          • Tanifuji Ryo
          • Haraguchi Naoto
          • Oguri Hiroki
          Chemo-enzymatic total syntheses of bis-tetrahydroisoquinoline alkaloids and systematic exploration of the substrate scope of SfmC.
          Tetrahedron Chem. 2022; : 100010
          • Liu Yannan
          • Schuppe Alexander W.
          • Zhao Yizhou
          • Lee Jaehoo
          • Newhouse Timothy R.
          Synthesis of melazolide B, a degraded limonoid, from a natural terpene precursor.
          Tetrahedron Chem. 2022; : 100011
          • Fan Lian-Feng
          • Liu Rui
          • Wang Pu-Sheng
          • Gong Liu-Zhu
          Modular access to chiral cyclopentanes via formal [2+2+1] annulation enabled by palladium/chiral squaramide relay catalysis.
          Tetrahedron Chem. 2022; 1: 100002
          • Wang Jing-Yi
          • Zhang Shuming
          • Xian-Yang Yu
          • Wang Yu-Hao
          • Wan Hong-Lin
          • Zhang Shu
          • Tan Wei
          • Shi Feng
          Organocatalytic asymmetric synthesis of bioactive hexahydropyrrolo[2,3-b]indole-containing tetrasubstituted allenes bearing multiple chiral elements.
          Tetrahedron Chem. 2022; 1: 100007
          • Liu Zhen
          • Yin Wei
          • Shi Min
          Visible-light-mediated interrupted Cloke-Wilson rearrangement of cyclopropyl ketones to construct oxy-bridged macrocyclic framework.
          Tetrahedron Chem. 2022; 1: 100001
          • Li Aimin
          • Liu Yuanchu
          • Zhou Wei
          • Jiang Yunqi
          • He Qing
          • Superphanes
          Facile and efficient preparation, functionalization and unique properties.
          Tetrahedron Chem. 2022; 1: 100006
          • Portela Susana
          • Fernández Israel
          Understanding the catalysis by bis-selenonium cations as bidentate chalcogen bond donors.
          Tetrahedron Chem. 2022; 1: 100008